ECM為肌肉骨骼領(lǐng)域（骨科、創(chuàng)傷、頜面（包括牙科）和脊柱）的臨床前研究提供了一個跨學(xué)科論壇。ECM期刊是由AO研究所DavOS，瑞士的非營利基金會出版的。生物醫(yī)學(xué)用材料評估手稿必須有一個重要的生物學(xué)維度，在細(xì)胞、組織或組織層面上報(bào)告效果。肌肉骨骼細(xì)胞的機(jī)械轉(zhuǎn)導(dǎo)紙?jiān)贓CM范圍內(nèi)。體外細(xì)胞相容性研究應(yīng)使用原代細(xì)胞或多個細(xì)胞系，并提供細(xì)胞活力、擴(kuò)散、增殖、礦化等的簡單描述?？煽紤]對體外、體外或體內(nèi)模型和相關(guān)意見文件進(jìn)行重大改進(jìn)。僅關(guān)注材料特性或生物力學(xué)特性（單獨(dú)或組合，沒有強(qiáng)大的生物學(xué)維度）的論文將不受歡迎。在防止細(xì)菌粘附方面，有關(guān)表面、涂層、添加劑等影響的手稿還必須考慮對真核細(xì)胞的影響（在摘要中提及），或參考使用完全相同表面的先前發(fā)布的數(shù)據(jù)。有關(guān)肌肉骨骼領(lǐng)域（定義見下文）內(nèi)的體外或體內(nèi)模型的感染預(yù)防、診斷、治療和重大改進(jìn)的高水平提交資料在ECM范圍內(nèi)。?組織工程和再生醫(yī)學(xué)（學(xué)期）將考慮有關(guān)肌肉骨骼領(lǐng)域內(nèi)結(jié)締組織和礦化組織修復(fù)或再生方面的手稿（見下文ECM的定義）。只使用生物力學(xué)測試的學(xué)期論文將不予考慮，但生物力學(xué)可以在學(xué)期內(nèi)提交。?結(jié)締組織和礦化組織的結(jié)構(gòu)、功能、生物學(xué)和生物力學(xué)將考慮有關(guān)骨骼、牙齒、軟骨、椎間盤、骨骼肌、肌腱和肌肉骨骼場（定義見下文ECM）內(nèi)韌帶結(jié)構(gòu)的手稿。?干細(xì)胞和祖細(xì)胞將考慮有關(guān)干細(xì)胞特征和分化機(jī)制的手稿，因?yàn)樗鼈兣c肌肉骨骼場的結(jié)締組織和礦化組織有關(guān)（如下面的ECM所定義）。注意：應(yīng)避免使用集合供者細(xì)胞。在不可避免的情況下，它們的使用需要在手稿（以及附信）中得到令人信服的證明。注：僅關(guān)注計(jì)算模型、材料模型或生物力學(xué)模型的技術(shù)說明和論文將不予受理。論文必須報(bào)告細(xì)胞、組織或組織水平的影響，這是可能接受在ECM中發(fā)表論文的先決條件。必須在摘要中簡要提及這項(xiàng)工作的臨床相關(guān)性，并在本文中進(jìn)行更詳細(xì)的介紹。摘要不好，不能簡明扼要地覆蓋論文內(nèi)容，將不送審?！峨娮由虅?wù)雜志》不接受研究中的增量步驟?？绶秶目鐚W(xué)科論文在ECM范圍內(nèi)。ECM對肌肉骨骼場的定義包括骨骼、牙齒、軟骨、椎間盤、骨骼?。ǚ瞧交』蛐募。?、肌腱和韌帶（不包括脊髓或神經(jīng)組織）。

ECM provides an interdisciplinary forum for publication of preclinical research in the musculoskeletal field (Orthopaedics, Trauma, Maxillofacial (including dental) and Spine). ECM Journal is published by the AO Research Institute Davos, a Not-for-Profit foundation in Switzerland.? Assessment of materials for biomedical useManuscripts must have an important biological dimension, reporting effects at the cellular, tissue or organismic levels. Mechanotransduction papers with musculoskeletal cells are within ECM scope. In vitro cytocompatibilty studies should use primary cells or more than one cell line and provide more than just simple descriptions of cell viability, spreading, proliferation, mineralisation etc. Major improvements with in vitro, ex vivo or in vivo models and relevant opinion papers may be considered. Papers focussing purely on material properties or biomechanics properties (alone or combined, without a strong biological dimension) will not be entertained. Manuscripts on effects of surfaces, coatings, additives etc. in preventing bacterial adhesion must also consider the effect on eukaryotic cells (to be mentioned within the abstract) or refer to previously published data using the exact same surfaces. High level submissions on infection prevention, diagnostics, therapy and major improvement with in vitro or in vivo models within the musculoskeletal field (as defined by ECM below) are within ECM scope.? Tissue Engineering and Regenerative Medicine (TERM)Manuscripts concerning aspects of the repair or regeneration of connective and mineralized tissues within the musculoskeletal field (as defined by ECM below) will be considered. TERM papers where only biomechanical testing is utilized will not be considered, but biomechanics may be within a TERM submission.? Structure, function, biology and biomechanics of connective and mineralized tissuesManuscripts concerning the structure of bone, teeth, cartilage, intervertebral discs, skeletal muscle, tendons and ligaments within the musculoskeletal field (as defined by ECM below) will be considered.? Stem and Progenitor CellsManuscripts concerning stem cell characterization and mechanisms of differentiation as they relate to the connective and mineralized tissues of the musculoskeletal field (as defined by ECM below) will be considered. Note: The use of pooled donor cells should be avoided. When unavoidable, their use needs to be justified convincingly within the manuscript (and within the cover letter). Note: Technical notes and papers focussing purely on computational, material or biomechanical models will not be entertained. Papers must report effects at the cellular, tissue or organismic levels, which is a pre-requisite for possible acceptance of papers for publication in ECM.The clinical relevance of the work must be briefly mentioned within the abstract and in more detail in the paper. Poor abstracts, which do not concisely cover the paper contents will not be sent for review. Incremental steps in research will not be entertained by ECM journal. Cross-disciplinary papers that go across our scope areas are within ECM scope.ECM 's definition of the musculoskeletal field includes bone, teeth, cartilage, intervertebral discs, skeletal muscle (not smooth or cardiac muscle), tendons and ligaments (it does not include the spinal cord or neural tissues).