該雜志發表了關于細胞、分子和結構生物學、發育生物學、細胞生理學和進化的所有方面的原始研究文章和評論。它將發表文章或評論，有助于從分子、細胞和組織的尺度和生物體理解活物質組織的基本生化和生物物理原理。這包括對理解生物化學和生物物理機制的貢獻，關于基本細胞和組織功能的結構-功能關系，發育，發育/進化關系，形態發生，干細胞生物學，疾病細胞生物學，植物細胞生物學的貢獻，以及對理解細胞器、細胞和組織水平的綜合過程的貢獻。利用高分辨率成像、活體成像、定量細胞生物學和集成生物學等方法作出貢獻;鼓勵使用創新的遺傳和表觀遺傳技術、體外組織工程、細胞、組織和綜合功能分析、定量生物學和建模來展示原始生物學原理。該雜志特別歡迎側重于細胞生物學與發育生物學、物理學、力學和化學之間的接口方法的貢獻。細胞功能的任何方面都可以提出理論和生物物理模型。方法的描述將被考慮，但它們的有效性應該由一個或多個應用程序來證明。歡迎在細胞和分子生物學、發育或細胞生理學方面具有影響的“組學”研究。期刊還發布了一個名為Scientiae論壇的專門討論和一般興趣版塊，其中包括以下主題的文章:模型和推測，細胞結構和功能的所有方面，旨在向在不相關領域工作的科學家開放特定主題的底稿綜述，以及將當前生命科學研究置于其歷史背景下的細胞生物學歷史。

The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms.This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.The journal welcomes, in particular, contributions focusing on approaches at the interface between cell biology and developmental biology, physics, mechanics and chemistry. Theoretical and biophysical models on any aspect of cell function can be submitted. Descriptions of methods will be considered but their validity should be demonstrated by one or more applications. “–omics” studies with impact in cellular and molecular biology, development or cell physiology are welcome.The Journal also publishes a specific discussion and general interest section called Scientiae Forum, that will include articles on the following topics: Models and Speculations, on all aspects of cell structure and function, Primer reviews aimed at opening-up specific topics to scientists working in unrelated fields of interest, and History of Biology of the Cell that will situate the present research in the life sciences within its historic context.